Treat with fever and heat
What is hyperthermia?
Treatment with hyperthermia is based on targeted heating of the body or individual parts of the body. The resulting "heat stress" makes the cancer cells more sensitive to the body's own degradation processes, accompanying radiation treatment or chemotherapy. However, the aim of the various hyperthermia procedures is not to kill the cancer cells directly through the heat.
The Center for Integrative Oncology offers moderate whole-body hyperthermia and passive local deep hyperthermia. Another procedure is active fever therapy. For more information on this procedure, see the flyer "Mistletoe therapy". Our center is a founding member of the Swiss-Hyperthermia-Network. All members of this network are obliged to provide treatment in accordance with the quality standards of the European Society for Hyperthermic Oncology (ESHO).
Publications and studies
The ZIO is a network member of the Swiss Hyperthermia Network. Founded in 2015, the Swiss Hyperthermia Network brings together 15 partner clinics across Switzerland to provide potential patients in Switzerland with access to hyperthermia treatment. The aim of the network is to provide evidence-based, interdisciplinary indications for all patients. The partner clinics hold a weekly virtual hyperthermia tumor board.
Ongoing studies
Ongoing Clinical Trials in Hyperthermia at KSA-KSB
1. muscle invasive bladder cancers
September 2012 - ongoing
A phase IIB study of the tetramodal therapy of T2-4NxM0 bladder cancer with hyperthermia combined with chemoradiotherapy following TUR-BT. (PI: Dr. B. Eberle / Dr. E. Puric, KSA).
End point
Primary: CR at end of treatment / Secondary: Functional bladder preservation, PFS and OS.
2. soft tissue sarcoma
October 2013 - ongoing till 2018
A phase I/II study of concurrent hyperthermia and proton beam radiotherapy in primary and recurrent unresectable soft tissue sarcoma. (PI: Prof. N.R. Datta, KSA). ClinicalTrials.gov NCT01904565.
End point
Primary: Local tumor control, Acute and late morbidity, wound complication / Secondary: Local control rate at 2 years, LDFS at 2 years.
3 Locally advanced pancreatic cancers
August 2016 - till 2021
A randomized phase II study of concurrent hyperthermia and chemoradiotherapy following neoadjuvant chemotherapy in locally advanced pancreatic cancers (HEATPAC). (PI: Prof. N.R. Datta, KSA). ClinicalTrials.gov NCT02439593.
End point
Primary: OS at 1 year, Acute and late morbidities / Secondary: Patterns of failure, PFS, DFS and OS.
4. inoperable chordomas
June 2016 - ongoing
Phase I/II feasibility study with hyperthermia and proton beam radiotherapy in inoperable chordomas. Sponsors: PSI, KSA-KSB.
End point
Primary: Feasibility Secondary: Response rates, subjective improvement in symptoms.
Ongoing Clinical Trials in Hyperthermia at Germany, Netherlands and Poland with hyperthermia
1. soft tissue sarcoma
July 2015 - July 2018
Trabactedin combined with regional hyperthermia as second line treatment for adult patients with advanced soft tissue sarcoma. Sponsors: Ludwig-Maximilians University of Munich, Klinikum Großhadern (Prof. R. Issels, Prof. Lars Linder). ClinicalTrials.gov NCT02359474.
End point
Primary: Progression free survival / Secondary: Overall survival.
2 Locally recurrent head and neck cancers
March 2017 - Feb 2022
HyBT-H&N: Salvage brachytherapy with interstitial hyperthermia for locally recurrent head & neck carcinoma following previously external beam radiation therapy. Sponsors: University Klinik of Erlangen, Germany (Prof. V. Strnad, Prof. R. Fitkau).
End point
Primary: Loco-regional control (salvage) / Secondary: Acute and late morbidity.
3. invasive bladder cancers
Feb 2017 - Jan 2022
HyBla-RCT: Organ preservation treatment in bladder cancers with chemoradiotherapy vs thermochamoradiotherapy. Sponsors: University Klinik of Erlangen, Germany.
End point
Primary: Loco-regional control / Secondary: Bladder preservation, Relapse free survival (local and distant), acute and late toxicity.
4. cancer cervix
Submitted for Ethical approval June 2017
HyZer_RCT_IBT: Multimodality therapy with chemoradiotherapy versus thermochemoradiotherapy and interstitial thermobrachytherapy.
End point
Primary: Overall survival / Secondary: Relapse free survival (local and distant), acute and late toxicity.
5. recurrent prostate cancer
Jan 2015
Regional hyperthermia and moderately dose-escalated salvage radiotherapy for recurrent prostate cancer: A phase II study. Sponsors: Charité, University Klinik Berlin, University Klinik of Tübingen (Dr. P. Ghajar).
End point
Primary: Acute GU toxicity.
6. recurrent prostate cancer
May 2015 - ongoing
Prostate BT-HT: A prospective phase II study of salvage brachytherapy in combination with interstitial hyperthermia for locally recurrent prostate carcinoma following external beam radiation therapy. Sponsors: M.Sklodowskiej-Curie, Krakow, Poland and University Klinik of Erlangen (Dr.A. Kukielka, Dr. V. Strnad).
End point
Primary: Loco-regional control / Secondary: acute and late toxicity.
7. resected pancreatic cancers
Sept 2013 - ongoing
A randomized two-armed open study on the adjuvant therapy in patients with R0/R1 resected pancreatic carcinoma with Gemcitabine plus Capecitabine (Arm GC) vs. Gemcitabine plus Cisplatin with regional hyperthermia (Arm GPH). Sponsors: Klinikum Grosshadern, Medical Center, University of Munich (Dr. K. Lechner, Prof. L. Linder, Prof. R. Issels). HEAT-Study EudraCT-No.: 2008-004802-14. ClinicalTrials.gov NCT01077427.
End point
Primary: Disease free survival / Secondary: Overall survival, acute and late toxicity.
8 Locally recurrent rectal cancers
March 2011 - ongoing
Neoadjuvant chemoradiation with 5-FU and Oxaliplatin combined with deep regional hyperthermia in locally recurrent rectal cancer. A multi-institutional phase I/II study (HyRec Trial). Sponsors: University Klinik of Erlangen, Germany (Prof. O.Ott, Prof. R. Fietkau). HyRec Trial Radiation Clinic 2009-010093-38. ClinicalTrials.gov NCT01716949.
End point
Primary: Feasibility rate / Secondary: Local progression-free survival, Distant metastasis-free survival (excluding M1 patients), Overall survival (excluding M1 patients), Response rate (RECIST criteria), Rate of curative resections (R0), Rate of acute and late toxicity.
9. anal cancers
Dec 2014 - April 2021
Phase 2 Randomized Trial to evaluate effects of deep regional hyperthermia in patients with anal carcinoma treated by standard radiochemotherapy (Hycan). Sponsors: University of Erlangen-Nuremberg Medical School (Dr. G. Grabenbauer). ClinicalTrials.gov NCT02369939.
End point
Primary: Improvement of complete remission / Secondary: Colostomy-free survival, Locoregional relapse-free survival, Overall relapse-free survival, Overall survival, Response rate, Acute and late toxicity, Quality of life.
10. localized prostate cancers
Presently not active
Prospective randomized phase III trial comparing postsurgical radiotherapy alone versus adjuvant radiotherapy plus hyperthermia in patients with localized prostate cancer. Sponsors: Academic Teaching Hospital Radiology Center of Fulda, Germany, Univ Hospital Verona, Italy (Dr. H.J. Feldmann, Prof. S. Maluta).
End point
Primary: Freedom from progression / Secondary: local-regional progression, distant metastases, disease-free survival, prostate cancer specific survival, nonprostate cancer specific survival, overall survival, and time to biochemical (PSA) failure, acute and late toxicity.
11 Muscle invasive bladder cancers
Details NA
Chemoradiation plus hyperthermia in muscle invasive bladder cancer: A phase II trial. (PI: M. Hulshof, Amsterdam).
End point
Details : NA.
12 Locally advanced rectal cancer
June 2018 - April 2024
Organ preservation in locally advanced rectal cancer by radiochemotherapy followed by consolidation chemotherapy (CAO/ARO/AIO-16). Sponsors / Collaborators: University Hospital Tübingen, Germany. ClinicalTrials.gov NCT03561142.
End point
Primary: Clinical complete response / Secondary: Local regrowth rate, safety, faecal incontinence, QOL, surgical interventions, surgical morbidity, pathological staging, R0 rate, rate of sphincter sparing surgery, relapse free survival, overall survival.
Relevant Clinical Trials worldwide listed in clinicaltrials.gov on hyperthermia for selected sites as on Jan'2020
1. cancer cervix
Recruiting
Modulated Electro-Hyperthermia plus Chemo-radiation for locally Advanced Cervical Cancer patients in South Africa. Interventions - Device: Modulated electro-hyperthermia / Radiation: External beam radiation / Drug: Cisplatin / Radiation: Brachytherapy.
Locations
Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, Gauteng, South Africa.
2. rectal cancer
Active, not recruiting
The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer. Interventions - Device: Electrohyperthermia.
Locations
Wonju Severance Christian Hospital, Wonju, Gangwon, Korea, Republic of.
3. rectal cancer
Recruiting
Neoadjuvant Chemoradiation with 5-FU(or Capecitabine) and Oxaliplatin Combined with Hyperthermia in Rectal Cancer. Interventions - Radiation: Radiotherapy / Procedure: Hyperthermia / Drug: 5-Fluorouracil / Drug: Capecitabine / Drug: Oxaliplatin.
Locations
Klinik Bad Trissl, Internal Medicine, Bad Trissl, Germany / University Hospital, Duesseldorf, Germany / Universitätsklinikum Erlangen, Strahlenklinik, Erlangen, Germany / LMU München, Campus Großhadern, Medizinische Klinik III, Hyperthermie, München, Germany / Schlossbergklinik, Oberstaufen, Germany / Universitätsklinikum Tübingen, Radioonkologie, Tübingen, Germany.
4 Locally Advanced Rectal Cancer
Terminated
Efficacy of NeoThermo-Radiochemotherapy for LA Rectal Cancer Before Laparoscopic TME: Prospective Phase II Trial. Interventions - Radiation: Hyperthermia with concurrent chemo-radiation therapy.
Locations
Samsung Medical Center, Seoul, Korea, Republic of.
5 Locally Advanced Rectal Cancer
Completed
Preoperative Radiochemotherapy with Hyperthermia for locally advanced Rectal Cancer. Interventions - Hyperthermia / Hyperthermic Radiochemotherapy / Hyperthermic Chemoradiotherapy / Deep Regional Hyperthermia / Other: Deep regional hyperthermia / Radiation: Radiotherapy / Drug: Chemotherapy (5-Fluorouracil).
Locations
University Hospital Tübingen, Department of Radiation Oncology, Tübingen, Baden-Württemberg, Germany.
6. rectal cancer
Recruiting
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy. Interventions - Radiation: Radiotherapy / Drug: Chemotherapy / Other: Deep regional hyperthermia.
Locations
University Hospital Erlangen, Erlangen, Germany / University Hospital Frankfurt, Frankfurt, Germany / University Hospital Tübingen, Tübingen, Germany / University Hospital Würzburg, Würzburg, Germany.
7. soft tissue sarcoma
Ongoing
Hyperthermia and Proton Therapy in Unresectable Soft Tissue Sarcoma. Interventions - Radiation: Hyperthermia and Proton Beam.
Locations
Kantonsspital Aarau, Aarau, Aargau, Switzerland / PSI, Viilligef / Univ Hosp Zurich /Balgrist Clinic, Zurich.
8. sarcoma
Completed
Combination Chemotherapy with or without Hyperthermia Therapy in Treating Patients with Soft Tissue Sarcoma. Interventions - Drug: doxorubicin hydrochloride / Drug: etoposide / Drug: ifosfamide / Procedure: conventional surgery / Procedure: hyperthermia treatment / Radiation: radiation therapy.
Locations
Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch, Berlin, Germany / Universitaetsklinikum Essen, Essen, Germany / Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany / Klinikum der Universitaet Muenchen - Grosshadern Campus, Munich, Germany.
9th Sarcoma, Alveolar Soft Part Sarcoma, Clear Cell Sarcoma, Malignant Peripheral Nerve Sheath Tumors, Myxoid Liposarcoma, Liposarcoma, Dedifferentiated, Synovial Sarcoma, Leiomyosarcoma, Undifferentiated Pleomorphic Sarcoma, Fibrosarcoma, Pleomorphic Rhabdomyosarcoma
Recruiting
Preoperative Hypofractionated Radiotherapy with Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas. Interventions - Radiation: Hypofractionated radiotherapy / Other: Hyperthermia.
Locations
Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Mazovian, Poland.
10. sarcoma
Recruiting
Hyper-Thermia Enhanced Antitumor Efficacy of Trabectedin. Interventions - Drug: Trabectedin / Genetic: DNA doublestrand breaks / Hyperthermia.
Locations
Ludwig-Maximilians University of Munich, Klinikum Großhadern, Munich, Bavaria, Germany / Helios Klinikum Bad Saarow, Bad Saarow, Germany / Charité - Universitätsmedizin Berlin, Berlin, Germany / Helios Klinikum Berlin-Buch, Berlin, Germany / Universitätsklinikum Erlangen, Erlangen, Germany.
11. pancreatic neoplasms
Unknown status
Hyperthermia with Chemotherapy for Locally Advanced or Metastatic Pancreas Cancer. Interventions - Device: Heckel Infrared Radiant Heat Device / Other: cisplatin, gemcitabine, interferonalpha / Other: thermochemotherapy.
Locations
Memorial Hermann Hospital, Houston, Texas, United States.
12. cancer pancreas
Unknown status
Multicenter RCT of the Clinical Effectiveness of Oncothermia with Chemotherapy in Metastatic Pancreatic Cancer Patients. Interventions - Other: Oncothermia / Drug: FOLFIRINOX or Gemcitabine based chemotherapy.
Locations
Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea, Republic of.
13. cancer pancreas
Recruiting
Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study. Interventions - Other: Chemoradiotherapy (CTRT) / Other: Thermochemoradiotherapy (CTRTHT).
Locations
Aarau Cantonal Hospital, Aarau, Aargau, Switzerland.
14 All Type of Cancers with Bony Metastasis.
Unknown status
Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients with Painful Bone Metastases. Interventions - Other: Hyperthermia / Radiation: External-beam radiotherapy.
Locations
Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Current publications
Current indications of deep hyperthermia at Kantonsspital Aarau with levels of evidence for each site and the related key citations
Indication: Cervix-Ca
- Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: A systematic review with conventional and network meta-analyses. Datta NR, Rogers S, Klingbiel D, et al. Int J Hyperthermia 2016 (in press).
- Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma. Lutgens L, van der Zee J, Pijls-Johannesma M, et al. Cochrane Database Syst Rev. 2010:CD006377.
- Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. Franckena M, Stalpers LJ, Koper PC, et al. Int J Radiat Oncol Biol Phys. 2008;70:1176-82.
- HDR brachytherapy combined with interstitial hyperthermia in locally advanced cervical cancer patients initially treated with concomitant radiochemotherapy-a phase III study. Zolciak-Siwinska A, Piotrkowicz N, Jonska-Gmyrek J, et al. Radiother Oncol 2013;109:194-9.
- A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma. Harima Y, Nagata K, Harima K, et al. Int J Hyperthermia 2001;17:97-105.
- Local thermo-radiotherapy in carcinoma cervix: Improved local control versus increased incidence of distant metastasis. Sharma S, Singhal S, Sandhu AP, et al. Asia Oceania J Obstet Gynaecol 1991;17:5-12.
- Thermoradiotherapy in the management of carcinoma cervix (stage IIIB): a controlled clinical study. Datta NR, Bose AK, Kapoor HK. Indian Med Gazette 1987;121: 68-71.
- A randomized trial of hyperthermia-radiochemotherapy for uterine cervix cancer. Chen HW, Fan JJ, Luo W. Zhonghua Zhong Liu Za Zhi 1997;24:249-51.
- A multicentre randomized clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer. Harima Y, Ohguri T, Imada H et al. Int J Hyperthermia. 2016 Nov;32(7):801-8.
- Radiation therapy combined with hyperthermia versus cisplatin for locally advanced cervical cancer: Results of the randomized. Lutgens LC, Koper PC, Jobsen JJ et al. J.radonc.2016.02.010.
- Network meta-analysis in locally advanced cervical cancer: evaluation of outcomes with chemoradiation therapy or thermoradiation therapy versus radiation therapy alone. Datta NR, Rogers S, Hutton B, et al. Int J Radiat Oncol Biol Phys 2016; 96(2), E324.
- Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: A systematic review with conventional and network meta-analysis. Datta NR, Rogers S, Klingbiel D, et al. SASRO 2016 (Awarded Best paper) Strahlenther Oncol 2016;192:832.
- Does hyperthermia with radiotherapy / chemoradiotherapy offer a therapeutic advantage in inoperable locally advanced cervix cancer? : A systematic review and network meta-analysis. Datta NR, Stutz E, Gomez S, et al. ESHO Berlin, 16-18 May 2018 (Oral presentation)
- Systematic review & network meta-analysis to identify the optimum nonoperative therapeutic strategies in locally advanced cervical cancer. Datta NR, Stutz E, Gomez S, Bodis S. SASRO 2018
- Therapeutic Options for Locally Advanced Cancer Cervix: A Systematic Review and Network Meta-analysis. Datta NR, Stutz E, Gomez S, Bodis S.. (Accepted for presentation), ASTRO 2018, San Antonio, Texas, USA.
- The effect of modulated electrohyperthermia on local disease control in HIV-positive and -negative cervical cancer women in South Africa: Early results from a phase III randomized controlled trial. Minnaar CA, Kotzen JA, Ayeni OA, et al. PLoS One 2019;14:e0217894.
- Efficacy and Safety Evaluation of the Various Therapeutic Options in Locally Advanced Cervix Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials. Datta NR, Stutz E, Gomez S, Bodis S. Int J Radiat Oncol Biol Phys 2019;103:411-437.
Indication: Bladder cancers
- Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group. van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, et al. Lancet 2000;355:1119-1125.
- Is hyperthermia combined with radiotherapy adequate in elderly patients with muscle-invasive bladder cancers? Thermoradiobiological implications from an audit of initial results. Datta NR, Eberle B, Puric E, et al. Int J Hyperthermia 2016 (in press) DOI: 10.3109/02656736.2015.1132340.
- Hyperthermia and radiotherapy in bladder cancer. Snider III J, Datta NR, Vujaskovic Z. Int J Hyperthermia 2016 20; 1-9.
- Quadrimodal treatment of high-risk T1 and T2 bladder cancer: transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia. Wittlinger M, Rödel CM, Weiss C, et al. Radiother Oncol. 2009 Nov;93(2):358-63.
- Thermoradiation in muscle invasive bladder cancer (MIBC): A Valuable therapeutic option for elderly or inoperable patients. Puric E, Datta NR, Eberle B, et al. ESHO 2017, Athens, June 23-25, 2017, p 38-39.
- Thermoradiotherapy in muscle invasive bladder cancer (MIBC) : a valuable therapeutic option for elderly or inoperable patients. Puric E, Datta NR, Eberle B, et al. SASRO 2017, St. Galen, June 8-10, 2017.
- Thermo-Radiotherapy in bladder cancer is a promising option in patients unfit for cystectomy or chemo-radiotherapy. Stutz E, Eberle B, Puric E, et al. SASRO 2018.
- A Pilot Study of Radiotherapy and Local Hyperthermia in Elderly Patients With Muscle-Invasive Bladder Cancers Unfit for Definitive Surgery or Chemoradiotherapy. Datta NR, Stutz E, Puric E, et al. Front Oncol 2019;9:889.
Indication: Rectal/Anal canal cancer
- Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer: Feasibility and long-term results from a phase II randomized trial. Kouloulias V, Plataniotis G, Kouvaris J, et al. Am J Clin Oncol 2005;28:91-9.
- Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group. van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, et al. Lancet 2000;355:1119-1125.
- Adjuvant VHF therapy in locally recurrent and primary unresectable rectal cancer. Trotter JM, Edis AJ, Blackwell JB, et al. Australas Radiol 1996;40:298-305.
- An alternative treatment of anal squamous cell carcinoma: Combined radiotherapy and chemotherapy. You YT, Wang JY, Changchien CR, et al. J Surg Oncol 1993;52:42-5.
- Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Berdov BA, Menteshashvili GZ. Int J Hyperthermia 1990;6:881-90.
- Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer. Gani C, Schroeder C, Heinrich V, et al. Int J Hyperthermia. 2016;32(2):187-92.
- Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses. Shoji H, Motegi M, Takakusagi Y, et al. Oncol Rep. 2017 Feb;37(2):695-704.
- Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer. Kim SW, Yea JW, Kim JH, Gu MJ, Kang MK. Int J Clin Oncol 2018;23:287-297.
- External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia. Zwirner K, Bonomo P, Lamprecht U, Zips D, Gani C. Int J Hyperthermia 2018;34:455-460.
- Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus. Ott OJ, Schmidt M, Semrau S, et al. Radiation Oncol 2019;195:607-614.
Indication: Soft tissue sarcoma
- Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Issels RD, Lindner LH, Verweij J, et al. Lancet Oncol 2010;11:561-570.
- Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumors: An open-label, non-randomized, single-institution, phase 2 study. Wessalowski R, Schneider DT, Mils O, et al. Lancet Oncol 2013;14:843-52.
- Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale. Datta NR, Puric E, Schneider R, et al. Int J Hyperthermia 2014;30:524-530.
- Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized HighRisk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial. Issels RD, Linder LH, Verweiji J, et al. JAMA Oncol. 2018 Feb 15;4:483-492.
- Early results of spot scanning proton therapy with hyperthermia in large inoperable sacral chordoma. Walser M, Datta NR, Puric E, et al. ESTRO Barcelona, Radiother Oncol 2018; 127 (suppl 1): s882-83.
- Hyperthermia combined with proton therapy in inoperable sacral chordomas: First clinical experience and early results. Puric E, Datta NR, Walser M, et al. ESHO 2018, 16-18 May 2018.
- First case report of concurrent proton therapy with hyperthermia in a large extra-abdominal desmoid tumor. Stutz E, Murray F, Puric E, et al. SASRO 2018.
- Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia. Iizumi T, Shimizu S, Numajiri H, et al. Int J Part Ther 2019;6:35-41.
- Early results and volumetric analysis after spotscanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas. Tran S, Puric E, Walser M, et al. Br J Radiol 2019:20180883.
- Neoadjuvant chemotherapy plus radiation versus chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a retrospective comparison. Zschaeck S, Wust P, Melcher I, et al. Int J Hyperthermia 2018;35:1-9.
- Radiotherapy and hyperthermia with curative intent in recurrent high risk soft tissue sarcomas. Eckert F, Braun LH, Traub F, et al. Int J Hyperthermia 2018;34:980-987.
Indication: Pancreatic carcinoma
- Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabinerefractory advanced pancreatic cancer. Tschoep-Lechner KE, Milan V, Berger F, et al. Int J Hyperthermia 2013; 29: 8-16.
- Phase II trial of combined regional hyperthermia and gemcitabine for locally advanced or metastatic pancreatic cancer. Ishikawa T, Kokura S, Sakamoto N, et al. Int J Hyperthermia 2012; 28: 597-604.
- Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : An open-label comparative cohort trial. Maluta S, Schaffer M, Pioli F, et al. Radiation Oncol 2011;187:619-25.
- Preclinical and clinical aspects of carboplatin and gemcitabine combined with whole-body hyperthermia for pancreatic adenocarcinoma. Bakshandeh-Bath A, Stotlz AS, Homann N, et al. Anticancer Res 2009; 29: 3069-3078.
- The effect of the combination therapy of hyperthermia and gemcitabine for the treatment of advanced inoperable pancreatic cancer. Takagi T, Kokura S, Ishikawa T, et al. 10th International Congress on hyperthermia Oncology, Munich, Germany, April 9 - 12, 2008, p. 50 (Abstract).
- Comparison of concomitant gemcitabine chemotherapy and local hyperthermia, gemcitabine monotherapy and local hyperthermia monotherapy for inoperable progressive pancreatic cancer. Yasuda M, Kondo M, Kokura S, et al. J Clin Oncol, 2008, 26: 15772 (abst).
- Intraoperative hyperthermia in conjunction with multi-schedule chemotherapy (pre-, intra- and post-operative) by-pass surgery and postoperative radiotherapy for the management of unresectable pancreatic adenocarcinoma. Kouloulias VE, Kouvaris JR, Nikita KS, et al. Int J Hyperthermia 2002;18: 233-52.
- "HEATPAC" - a phase II randomized study of concurrent thermochemoradiotherapy versus chemoradiotherapy alone in locally advanced pancreatic cancer. Datta NR, Pestalozzi B, Clavien PA, et al. Radiat Oncol. 2017 Nov 21;12(1):183.
- A phase II randomized study of concurrent hyperthermia and chemoradiotherapy vs chemoradiotherapy alone in locally advanced pancreatic cancer (HEATPAC): first information and call for participation. Datta NR, Pestalozzi B, Clavien P, et al, HEATPAC Trial Group. (ClinicalTrials.gov Identifier: NCT02439593) ESHO 2017, Athens, June 23-25, 2017, p 56-57.
Indication: Deep seated bony metastasis
- Comparing the effectiveness of combined external beam radiation and hyperthermia versus external beam radiation alone in treating patients With painful bony metastases: A Phase 3 Prospective, Randomized, Controlled Trial. Chi MS, Yang KL, Chang YC, et al. Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):78-87.
- Evaluating the effectiveness of combined radiotherapy and hyperthermia for the treatment response of patients with painful bony metastases: A phase 2 clinical trial. Ariyafar T, Mahdavi SR, Geraily G, et al. J Therm Biol 2019;84:129-135.
Contributions by KSA to promote hyperthermia in National and International scientific forums (2018 -2019)
- Awarded "European Society of Hyperthermic Oncology (ESHO) Member of Merit". December 2019 (Prof. N. R. Datta)
- Elected Board Member, European Society of Hyperthermic Oncology (ESHO). (Prof. N. R. Datta).
- Publications related to hyperthermia (2018-19): Full length articles in peer-reviewed journals: 7
- Keynote presentations at the Annual Conference of the European Society of Hyperthermic Oncology (ESHO). Warsaw, 2019 (Prof. S. Bodis, Prof. N. R. Datta).
- Keynote presentations at the Annual Conference of the International Conference of Hyperthermia Oncology (ISHO). 2018 (Budapest) and 2019 (Thessalonski). (Prof. S. Bodis, Prof. N. R. Datta).
- Coordinated the proposal for first ever multi-centric clinical trial proposal meeting in hyperthermia, endorsed by ESHO. Nov 2019, Amsterdam. (Prof. S. Bodis).
- One of the main collaborators for the EU Grant proposal to develop Hyperthermia boosting the effect of Radiotherapy (HYPERBOOST): Decision awaited.
- Submitted proposal for a Panel session on Hyperthermia at the forthcoming American Society for Therapeutic Radiaology and Oncology (ASTRO). 2019: Decision awaited.
- Conducted an Educational Session at the Scientific Association for Swiss Radiation Oncology (SASRO) conference. 2019 entitled, "Hyperthermia: Overview of Clinically Validated Indications".
- Invited to propose and conduct a Special Sessions on "Hyperthermia" at the forthcoming Scientific Association for Swiss Radiation Oncology (SASRO) conference. 2020.
Hyperthermia tumor board
As part of the Swiss Hyperthermia Network, the ZIO participates in the weekly Hyperthermia Tumor Board.
Weekly on Monday, 4:30 pm
Go directly to registration >
Local deep hyperthermia
Localized deep hyperthermia can be used to treat local and regional tumours. A temperature of 42 to 44 degrees Celsius is generated for a period of 50 minutes using so-called short-wave radiation. This heat triggers various reactions in the cancer cell that can lead to its destruction. Healthy tissue is not damaged in the process.
More info
The treatment takes place on a therapy bed, which is equipped with support tiles and a tile electrode. The tile electrode and another electrode are positioned specifically on the body region to be treated. During therapy, radio waves with a frequency of 13.56 megahertz flow through the area of the body between the two electrodes. Various settings can be made, controlled and changed via a display before and during the treatment. In addition, a computer continuously monitors all safety-relevant parameters during the treatment and is used for detailed documentation. The treatment can be interrupted by the patient at any time. In contrast to surgery, chemotherapy and radiotherapy, hyperthermia has virtually no side effects. You may even feel very comfortable during the treatment.
In individual cases, it may be more difficult to treat a tumor that is located in the immediate vicinity of a hip or knee joint replacement. Patients with impaired temperature perception can only be treated with special monitoring. Unfortunately, therapy with local deep hyperthermia is not possible for patients with pacemakers and other pacemaker electrodes.
Moderate whole-body hyperthermia
The healthy body reacts to pathogenic stimuli with temperature increases up to high fever. Accordingly, artificially raising the body temperature can also stimulate the blocked self-healing powers in chronic and malignant diseases. In moderate whole-body hyperthermia, heat is supplied by infrared radiation with a high proportion of water-filtered infrared A. This radiation penetrates deep into the body. This radiation penetrates so deeply into the tissue and subcutaneous tissue that the heat released can be absorbed by the blood and distributed throughout the body. This is achieved through uniform and skin-friendly radiation.
More info
When is whole-body hyperthermia used?
- Supplementary use for cancer
- Fibromyalgia syndrome and chronic fatigue syndrome
- Rheumatism
- Chronic skin diseases, e.g. psoriasis and others
How is the treatment carried out?
Moderate whole-body hyperthermia consists of three phases:
- Warm-up phase of approx. 90 to 120 minutes, during which the body temperature rises
- Heat accumulation phase of approx. 120 minutes, during which the maximum body temperature should be maintained
- Relief phase in which the body temperature returns to normal